While in Southern Oregon, I recommend spending time in the quaint town of Ashland, taking in a Shakespearean theater production or dining at one of the many farm-to-fork restaurants. If time permits, a day trip to Crater Lake National Park is a must: the route from Ashland (or anywhere in Southern Oregon) will take you past Union Creek and several lava tube sections of the Rogue River. During the warm months, I recommend a day on the Rogue River, rafting or fishing, and in winter, various snow sports are on tap at Mt. Ashland.
If you’re into breweries, Medford and Ashland have several great locations, such as Caldera and Standing Stone, or if wine’s more your thing, I recommend a day on the Applegate Wine Trail (outside historic Jacksonville). If you let me know your interests, I know I could tailor my answer to you better!