Well, seeing the Sisters on the way to Mt. Hood isn’t exactly the direct route, but if you are up for a leisurely driving tour of the state, it’s a lovely way to go! From Newport you can head east over the Cascades, seeing many lovely sights along the way. From Bend, head north on Hwy 97 to Mt. Hood. The whole endeavor will take you seven hours +, so if you have time, you might consider staying over a night (maybe in Bend?). You can see the Cascades from parts of I-5 (assuming you took a more direct route from Newport to Hood), but it isn’t nearly the same as seeing those peaks up close.