A girls weekend sounds fabulous! You really can’t go wrong in any part of the Willamette Valley if you’re looking for wine, food and fun. Since you specifically asked about something that’s reasonably priced, I’m going to pass along a few ideas for places to stay that I know are a bit off the beaten path and somewhat easier on the budget.
The Grand Hotel in Salem offers a Wine Trail package that is a good deal. I’ve stayed at the Grand and it’s a very comfortable hotel, and it’s an easy drive to the Eola-Amity Hills AVA, which has absolutely world-class wineries. However, because it’s further from Portland, lodging in this area is a little less expensive — and the wineries may be a little crowded on a weekend (although nothing in Oregon will be crowded compared to wine regions like Napa).
Consider staying at Sweet Cheeks Winery Farmhouse. Since you’re traveling in a group, perhaps a house rental in a vineyard might be fun? Divided out among the members of your group, the price per night is probably lower than booking individual hotel rooms. It’s right next to Sweet Cheeks winery, which is one of my favorite wineries in the South Willamette Valley; lots of other great wineries in this region, including King Estate, which is stunning and has a wonderful winery restaurant which would be great for a special dinner together.
If you’re looking for something budget-friendly in the northern part of the Willamette Valley (Dundee Hills, Carlton, Newberg, McMinnville), which is where many of Oregon’s most famous wineries are, I’d suggest Hotel Oregon. It’s a renovated historic hotel on 3rd Street in downtown McMinnville, and is walking distance to tasting rooms and great restaurants (plus the hotel has a restaurant and four bars onsite!). The rooms in this hotel are European style, which means they are on the smaller side and some of them have shared bathrooms accessed via the hallway (other rooms with private baths are available too). But the rooms are all very nice and decorated with quirky hand-painted murals. I’ve stayed there and had a great time! Plus you really cannot beat the prices at this place for a historic hotel in the heart of Oregon Wine Country.